Research Citations
Applied Viromics is proud to have supported leading scientific research across molecular biology, neurobiology, gene therapy, oncology, and immunology. Below is a curated list of peer-reviewed publications featuring our recombinant AAV and adenoviral vectors.
High-Throughput Sequencing Reveals Principles of Adeno-Associated Virus Serotype 2 Integration
Journal of Virology 2013; 87(15):8559-8568.
Adeno-associated virus type 2 preferentially integrates single genome copies with defined breakpoints
Virology Journal 2014; 11(15).
Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells
BioMed Central (BMC) 2007; 7(111).
Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival
Molecular Cancer 2008; 7(78).
Serum/glucocorticoid-induced protein kinase-1 facilitates androgen receptor-dependent cell survival
Cell Death and Differentiation 2007; 14: 2085–2094.
Reduction of arthritis following intra-articular administration of an adeno-associated virus serotype 5 expressing a disease-inducible TNF-blocking agent
Annals of the Rheumatic Diseases: The Eular Journal 2007; 66:1143-1150.
Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats
American Diabetes Association: Diabetes 2011; 60(11): 2691-2700.
Successful Amelioration of Mitochondrial Optic Neuropathy Using the Yeast NDI1 Gene in a Rat Animal Model
PLoS One 2010; 5(7).
Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma
Molecular Vision 2010; 16: 1331-1342.
Hypothalamic Leucine Metabolism Regulates Liver Glucose Production
American Diabetes Association: Diabetes 2012; 61(1): 85-93.
Anti-viral state segregates two molecular phenotypes of pancreatic adenocarcinoma: potential relevance for adenoviral gene therapy
Journal of Translational Medicine 2010; 8(10).
Faithful Expression of Multiple Proteins via 2A-Peptide Self-Processing: A Versatile and Reliable Method for Manipulating Brain Circuits
The Journal of Neuroscience 2009; 29(27): 8621-8629.
Protective Role of rAAV-NDI1, Serotype 5, in an Acute MPTP Mouse Parkinson's Model
Parkinson's Disease 2011; 2011.
Efficient Sleeping Beauty DNA Transposition From DNA Minicircles
Molecular Therapy Nucleic Acids 2013; 2.
Identification of a cellular node for motor control pathways
Nature Neuroscience 2014; 17(4):586-593.
No immune responses by the expression of the yeast Ndi1 protein in rats
PLoS One 2011; 6(10).
Local delivery of beta interferon using an adeno-associated virus type 5 effectively inhibits adjuvant arthritis in rats
Journal of General Virology 2007; 88: 1717-1721.
Role of cellular FKBP52 protein in intracellular trafficking of recombinant adeno-associated virus 2 vectors
Virology 2006; 353(2): 283-293.
Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-α Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia
The Journal of Neuroscience 2012; 32(28): 9457-9468.
Adeno-associated virus–delivered short hairpin-structured RNA for androgen receptor gene silencing induces tumor eradication of prostate cancer xenografts in nude mice: A preclinical study
International Journal of Cancer 2010; 126(3): 764-774.
Potential for Promoting Recurrent Laryngeal Nerve Regeneration by Remote Delivery of Viral Gene Therapy
The Laryngoscope 2012; 122: 349-355.